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The contribution of sleep quality and psychological factors to the experience of within-day pain fluctuations among individuals with temporomandibular disorders.

We assessed the impact of day-to-day sleep quality and psychological variables (catastrophizing, negative affect, positive affect) to within-day pain fluctuations in 42 females with painful temporomandibular disorders (TMD) using electronic […]

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HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study.

Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We […]

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Prevalence and Risk Factors of Multi-type Post-COVID Pain in a Cohort of Previously Hospitalized COVID-19 Survivors: A Danish Cross-Sectional Survey.

This population-based study investigated the prevalence of de novo, multi-type, post-COVID pain and its associated risk factors in previously hospitalized COVID-19 survivors. The nationwide, cross-sectional study included a cohort of […]

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Endocrine aspects of pain pathophysiology: Focus on adipose tissue.

Multiple factors, including neurobiological, hormonal, psychological, and social/cultural norms influence the manner in which individuals experience pain. Adipose tissue, once considered solely an energy storage site, has been recognized as […]

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The Autobiographical Memory System and Chronic Pain: A Neurocognitive Framework for the Initiation and Maintenance of Chronic Pain.

Chronic pain affects approximately 20% of the world’s population (1), exerting a substantial burden on the affected individual, their families, and healthcare systems globally. Deficits in autobiographical memory have been […]

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Subcutaneous administration of Stattic alleviates neuropathic pain by relieving inflammation in a mouse model of postherpetic neuralgia.

Stattic, a commercial inhibitor of STAT3, can drive the development of neuropathic pain. Exploring the connection between Stattic and JAK1/STAT3 signaling may facilitate the understanding of neuropathic pain caused by […]

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Fenofibrate ameliorates nitroglycerin-induced migraine in rats: Role of CGRP/p-CREB/P2X3 and NGF/PKC/ASIC3 signaling pathways.

Migraine, a debilitating neurological condition, significantly affects patients’ quality of life. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist approved for managing dyslipidemia, has shown promise in treating neurological disorders. […]

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Efficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double-blind, placebo-controlled, multicentre phase 3 trials.

Patients with hidradenitis suppurativa have substantial unmet clinical needs and scarce therapeutic options. We aimed to assess the efficacy and safety of bimekizumab, a monoclonal IgG1 antibody that selectively inhibits […]

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A regulatory role of the medial septum in the chloroquine-induced acute itch through local GABAergic system and GABAergic pathway to the anterior cingulate cortex.

Itch, a common somatic sensation, serves as a crucial protective system. Recent studies have unraveled the neural mechanisms of itch at peripheral, spinal cord as well as cerebral levels. However, […]

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Molecular design, construction and analgesic mechanism insights into the novel transdermal fusion peptide ANTP-BgNPB.

Toad venom, a traditional Chinese medicine, exhibits remarkable medicinal properties of significant therapeutic value. The peptides present within toad venom possess a wide range of biological functions, yet the neuropeptide […]

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