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Papers of the Week

Papers: 25 May 2024 - 31 May 2024

2024 May 27

BMC Musculoskelet Disord




How well do participants in clinical trials represent the U.S. population with chronic neck or back pain?


Leininger BD, Johnson PJ, Bronfort G, Kuntz KM, Enns E, Hodges JS, Evans R


Randomized clinical trials (RCTs) are the gold standard for assessing treatment effectiveness; however, they have been criticized for generalizability issues such as how well trial participants represent those who receive the treatments in clinical practice. We assessed the representativeness of participants from eight RCTs for chronic spine pain in the U.S., which were used for an individual participant data meta-analysis on the cost-effectiveness of spinal manipulation for spine pain. In these clinical trials, spinal manipulation was performed by chiropractors.