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Papers of the Week

Papers: 25 May 2024 - 31 May 2024

2024 May 28

J Headache Pain




PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice.


Son H, Zhang Y, Shannonhouse J, Gomez R, Kim YS


Pain, an evolutionarily conserved warning system, lets us recognize threats and motivates us to adapt to those threats. Headache pain from migraine affects approximately 15% of the global population. However, the identity of any putative threat that migraine or headache warns us to avoid is unknown because migraine pathogenesis is poorly understood. Here, we show that a stress-induced increase in pituitary adenylate cyclase-activating polypeptide-38 (PACAP38), known as an initiator of allosteric load inducing unbalanced homeostasis, causes headache-like behaviour in male mice via mas-related G protein-coupled receptor B2 (MrgprB2) in mast cells.