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The impact of rumination on fibromyalgia pain after physical activity: an experimental study.

Some fibromyalgia (FM) patients engage in rumination (i.e. a chain of repetitive, passive and relatively uncontrollable thoughts focused on negative content) to cope with the pain and discomfort of daily […]

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TET1-mediated epigenetic regulation of tumor necrosis factor-α in trigeminal ganglia contributes to chronic temporomandibular joint pain.

Chronic temporomandibular joint (TMJ) pain profoundly affects patients’ quality of life. Trigeminal tumor necrosis factor-α (TNFα) plays a pivotal role in mediating TMJ pain in mice, yet the underlying epigenetic […]

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Examination of conditioned pain modulation in myofascial TMD with consideration of temporal summation.

Research on myofascial temporomandibular disorder (mTMD) has often focused on potential dysfunction in endogenous pain modulation. However, studies on the specific inhibitory and facilitatory components of endogenous pain modulation using […]

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Wireless transcutaneous electric nerve stimulation (TENS) for chronic chemotherapy-induced peripheral neuropathy (CIPN): a proof-of-concept randomized clinical trial.

Chemotherapy-induced peripheral neuropathy (CIPN) affects approximately 30%-60% of people who receive neurotoxic chemotherapy. CIPN is associated with impaired quality of life and function and has few effective treatments. This 6-site, […]

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Ibuprofen modulates tetrodotoxin-resistant persistent Na currents at acidic pH in rat trigeminal ganglion neurons.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve various symptoms such as headache, arthralgia, and dental pain. While the primary mechanism of NSAID-based pain relief is the inhibition of […]

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Spontaneous activity in peripheral sensory nerves: a systematic review.

In the peripheral nervous system, spontaneous activity in sensory neurons is considered to be one of the 2 main drivers of chronic pain states, alongside neuronal sensitization. Despite this, the […]

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Novel endomorphin analogs CEMR-1 and CEMR-2 produce potent and long-lasting antinociception with a favorable side effect profile at the spinal level.

Endomorphins (EMs) have shown great promise as pharmaceutics for the treatment of pain. We have previously confirmed that novel EM analogs CEMR-1 and CEMR-2 behaved as potent μ-opioid receptor agonists […]

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ME3183, a novel phosphodiesterase-4 inhibitor, exhibits potent anti-inflammatory effects and is well tolerated in a non-clinical study.

Phosphodiesterase 4 (PDE4) inhibitors are expected to exhibit efficacy against inflammatory diseases due to their broad pharmacological activity. The launched PDE4 inhibitors apremilast, crisaborole, and roflumilast have not exhibited sufficient […]

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Temporal summation of the thermal grill illusion is comparable to that observed following noxious heat.

The thermal grill illusion (TGI) describes a peculiar or even painful percept caused by non-noxious, interlaced warm and cold stimuli. It involves the glutamatergic system and is affected in putatively […]

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Buprenorphine use in the United States, 2010-2019.

Buprenorphine is effective for the treatment of opioid use disorder and chronic pain, has a safer pharmacological profile than full-mu opioid agonists, and can now be prescribed by any U.S. […]

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