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Opioids provide powerful relief from pain, but their many serious side effects include a paradoxical increase in pain, a phenomenon referred to as opioid-induced hyperalgesia (OIH), in patients and animals. […]
Learn More >Chronic pain has long been associated with peripheral nerve damage or local inflammation. However, chronic pain often has no clinically obvious cause. A new study proposes that long-term potentiation (LTP)—a […]
Learn More >The International Association for the Study of Pain (IASP) Definition of Pain Task Force has proposed an update to the organization’s official definition of pain to help better guide future […]
Learn More >Editor’s note: The 17th IASP World Congress on Pain took place September 12-16, 2018, in Boston, US. At the Congress, 12 early-career pain researchers took part in the PRF Correspondents Program, a science communications training […]
Learn More >There are no effective treatments to prevent or reverse osteoarthritis (OA), a progressive, degenerative condition where joint cartilage, joint structures, and underlying bone come under attack. Nor are there safe […]
Learn More >The naked mole rat—unsightly in appearance, unconventional in its habitat, and unusual in its physiology—has been a boon to pain researchers, who have spent the past decade investigating the animal’s […]
Learn More >Editor’s note: The following is a summary of the John Bonica Named Lecture delivered at the Australian Pain Society 39th Annual Scientific Meeting. John Bonica—widely regarded as the founding father […]
Learn More >Migraine is the second most disabling condition worldwide, trailing only low back pain, yet it remains neglected as a field of research. To help bridge the gap, this year’s American […]
Learn More >Spinal cord pain processing is a complicated phenomenon involving different neurobiological mechanisms and molecular players. Dorsal horn disinhibition spurred by brain-derived neurotrophic factor (BDNF) and excitation mediated by NMDA receptors […]
Learn More >The anterior cingulate cortex (ACC) has long been known as a key node in processing affective components of pain in animals and people. But little is known about the ACC […]
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