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Does Dendritic Spine Plasticity Contribute to Pain? The Evidence Is Mushrooming

Dendritic spines – small protrusions from the dendrites of neurons – have been familiar to neuroscientists for more than a century, especially to those studying the neuronal mechanisms of learning […]

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When Mice Make Faces, Machine Learning to the Rescue!

When a person feels disgust, fear, or pain, there’s a good chance an observer can identify those emotions from the facial expressions of the individual they are watching. But what […]

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A Paradox of Thermosensation in Mice: Perceiving Warmth Requires a Cool-Activated Channel

Can mice perceive slight rises in temperature as warming? A new study says yes, and asserts that patterns of sensory afferent activity, rather than dedicated cold and warm pathways known […]

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Switch to Telehealth During COVID-19 Pandemic Seen as “Silver Lining” of a Great “Natural Experiment”

As the COVID-19 pandemic sweeps around the globe, shuttering schools and businesses, pain clinics and therapists’ offices have closed, too. As a result, people with chronic pain swiftly lost access […]

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Fibroblasts Join the Ranks of Pain Targets

An obscure protein has emerged as a key control point in immune cell infiltration of the dorsal root ganglia (DRG) and peripheral nerves after injury. The protein, a protease inhibitor […]

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Turning Pluripotent Stem Cells Into a New Population of Sensory Neurons

A number of pain labs are now using human tissue, primarily dorsal root ganglia (DRG), to learn more about species differences in pain between animals and people, and to improve […]

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COVID-19 Hits Pain Research Labs Hard

As the COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 sweeps around the globe, business as usual has come to a screeching halt. Schools and universities, shops, and offices have […]

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Brain Networks Controlling Endogenous Pain Modulation Differ According to Age and Sex

Over the next several decades, a rapid increase in aging populations will challenge healthcare systems around the world. This is particularly true for efforts to treat pain, since the prevalence […]

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Hunting for the Macrophage MAFIA in Neuropathic Pain

Immune cell recruitment and activation after nerve injury contribute to neuropathic pain, and recent studies have aimed to identify the types of immune cells and neuroimmune interactions that play a […]

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TACAN: A New Mechanical Pain Sensor

Mechanotransduction is the process by which a mechanical stimulus is converted into an electrical signal, allowing us to hear, feel touch, and experience pain, among other sensations. But much remains […]

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