I am a
Home I AM A Search Login

Sex Differences

Share this

CoREST1 in primary sensory neurons regulates neuropathic pain in male mice.

Epigenetic regulation is implicated in the neurogenesis of neuropathic pain. The repressor element 1 (RE1) silencing transcription factor (REST) corepressor (CoREST) proteins function as corepressors in the REST complex and/or […]

Learn More >

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury.

Osteoarthritis is a disease with sex-dependent prevalence and severity in both humans and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and […]

Learn More >

Adolescent alcohol exposure produces sex-specific long-term hyperalgesia via changes in central amygdala circuit function.

Exposure to alcohol during adolescence produces many effects that last well into adulthood. Acute alcohol is analgesic and people living with pain report drinking alcohol to reduce pain, but chronic […]

Learn More >

A lower frequency of inflammatory back pain in male patients with ankylosing spondylitis compared with female patients.

In routine rheumatology practice, we noticed that a significant number of male ankylosing spondylitis (AS) patients did not experience inflammatory back pain (IBP). Based on this observation, we aimed to […]

Learn More >

Phosphorylation of the AMPARs regulated by protein kinase C (PKC) and protein interacting with C-kinase 1 (PICK1) contribute to orofacial neuropathic pain.

The α-amino-3-hydroxy-5-methylisoxazole-4-isoxazolepropionic acid receptor (AMPAR) has been recognized to play a vital role in the development of neuropathic pain. Recent studies have indicated that protein kinase C (PKC) and protein […]

Learn More >

Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders.

Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we report the discovery and characterization of first-in-class, humanized PRL neutralizing […]

Learn More >

Translational research updates in female health anesthesiology: a narrative review.

Females represent 49.6% of the global population and constitute a significant proportion of surgical patients and hospital admissions. Little is known about the bi-directional effects of sex and anesthetics or […]

Learn More >

The antidepressant drugs vortioxetine and duloxetine differentially and sex-dependently affect animal well-being, cognitive performance, cardiac redox status and histology in a model of osteoarthritis.

Osteoarthritis represents a leading cause of disability with limited treatment options. Furthermore, it is frequently accompanied by cardiovascular and cognitive disorders, which can be exacerbated by osteoarthritis or drugs used […]

Learn More >

Psoriatic arthritis: improvement in outcomes but persistent sex difference – 5-year follow-up study of a Norwegian outpatient clinic population.

This study aimed to explore long-term changes in disease activity and remission rates, and potential sex-related differences in these outcomes, in psoriatic arthritis (PsA) patients treated in an outpatient clinic.

Learn More >

Sexual Dimorphism in the Mechanism of Pain Central Sensitization.

It has long been recognized that men and women have different degrees of susceptibility to chronic pain. Greater recognition of the sexual dimorphism in chronic pain has resulted in increasing […]

Learn More >