I am a
Home I AM A Search Login

Papers of the Week


Papers: 16 Sep 2023 - 22 Sep 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Genetics, Neurobiology, Sex Differences

PAIN TYPE:
Arthritis, Inflammation/Inflammatory


2023 Sep 14


Osteoarthritis Cartilage


37716404

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury.

Authors

Bergman RF, Lammlin L, Junginger L, Farrell E, Goldman S, Darcy R, Rasner C, Obeidat AM, Malfait AM, Miller RE, Maerz T

Abstract

Osteoarthritis is a disease with sex-dependent prevalence and severity in both humans and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic osteoarthritis (PTOA).