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Invisible cost of pain management by the current International Classification of Diseases coding system, a study in a tertiary care inpatient setting.

The International Classification of Diseases (ICD) is applied worldwide for public health data collection among other use cases. However, the current version of the ICD (ICD-10), to which the reimbursement […]

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The Utility of a Novel, Combined Biofeedback-Virtual Reality Device as Add-on Treatment for Chronic Migraine: A Randomized Pilot Study.

To determine if frequent use of a combined biofeedback-virtual reality device improves headache-related outcomes in chronic migraine.

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The fetal pain paradox.

Controversy exists as to when conscious pain perception in the fetus may begin. According to the hypothesis of cortical necessity, thalamocortical connections, which do not form until after 24-28 weeks […]

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“You have to believe the patient”: What do people with fibromyalgia find helpful (and hindering) when accessing health care?

Fibromyalgia (FM) is a complex, still poorly understood, and difficult-to-treat chronic pain condition for which many people struggle to find adequate care.

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An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact.

Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in general population and particularly in vulnerable populations. Despite its wide use, debate exists regarding the analgesic mechanism of action […]

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Migraine and the Gender Divide.

Migraine is a global neurologic disease that is highly prevalent, especially in women. Studies have observed a predisposition for the development of migraine in women, although the mechanisms involved have […]

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Get your head in the game: a replicated single-case-experimental-design evaluating the effect of a novel virtual reality intervention in people with chronic low back pain.

Chronic low back pain (CLBP) is a leading cause of disability worldwide. Contemporary treatment of CLBP is suboptimal, with small/moderate effect sizes and high relapse rates. Virtual reality (VR) is […]

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Serum metabolomic profiling identifies potential biomarkers in arthritis in older adults: an exploratory study.

Seronegative elderly-onset rheumatoid arthritis (EORA) and polymyalgia rheumatica (PMR) have similar clinical characteristics making them difficult to distinguish based on clinical features. We hypothesized that the study of serum metabolome […]

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Treatment decisions in axial spondyloarthritis daily clinical practice are more than treat-to-target.

‘Treat-to-target principles’ are advised for axial spondyloarthritis although a clear target is not yet defined and targets do not always reflect inflammation. Treat-to-target use and motives for treatment choices in […]

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Clinical outcome data of chronic pain patients treated with cannabis-based oils and dried flower from the UK Medical Cannabis Registry.

The following study evaluated the clinical outcomes of patients enrolled in the UK Medical Cannabis Registry, who were treated with inhaled dried flower (Adven® EMT2, Curaleaf International, Guernsey), and sublingual/oral […]

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