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Epigenomic profiling of mouse nucleus accumbens at single-cell resolution.

The nucleus accumbens (NAc) is a key brain region involved in reward processing and is linked to multiple neuropsychiatric conditions such as substance use disorder, depression, and chronic pain. Recent […]

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Profiling migraine patients according to clinical and psychophysical characteristics: a cluster analysis approach.

This study aims to profile migraine patients according clinical and psychophysical characteristics.

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Gadolinium contrast agents: dermal deposits and potential effects on epidermal small nerve fibers.

Small fiber neuropathy (SFN) affects unmyelinated and thinly myelinated nerve fibers causing neuropathic pain with distal distribution and autonomic symptoms. In idiopathic SFN (iSFN), 30% of the cases, the underlying […]

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The impact of ethnic discrimination on chronic pain: the role of sex and depression.

Perceived ethnic discrimination (PED) is predictive of chronic pain-related outcomes. Less is known about pathways through which these constructs interact. The goal of this study was to test whether PED […]

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The global, regional, and national burden of inflammatory bowel diseases, 1990-2019: A systematic analysis for the global burden of disease study 2019.

In recent years, the global epidemiology of inflammatory bowel disease (IBD) has changed rapidly.

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Efficacy of Roflumilast Foam, 0.3%, in Patients With Seborrheic Dermatitis: A Double-blind, Vehicle-Controlled Phase 2a Randomized Clinical Trial.

Current topical treatment options for seborrheic dermatitis are limited by efficacy and/or safety.

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Association Between Depression and Physical Conditions Requiring Hospitalization.

Depression is associated with an increased risk of physical illness, but the most common causes of hospitalization among people with depression are unclear.

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Mental disorder prevalence in chronic pain patients using opioid versus non-opioid analgesics: A registry-linkage study.

Chronic pain and mental disorders are leading causes of disability worldwide. Individuals with chronic pain are more likely to experience mental disorders compared to individuals without chronic pain, but large-scale […]

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Sustained response of galcanezumab in migraine prevention: Patient-level data from a post hoc analysis in patients with episodic or chronic migraine.

To evaluate, at population and individual patient levels, the sustained response of reduction in migraine headache days in patients with migraine treated with galcanezumab.

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Glass half full: A diary and interview qualitative investigation of flourishing among adolescents living with chronic pain.

Counter to paediatric pain literature that typically highlights the deleterious impacts associated with adolescent chronic pain, evidence suggests that some adolescents flourish in their experience of pain. This study sought […]

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