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Papers of the Week

Papers: 29 Apr 2023 - 5 May 2023

Basic Science, Methodology

Genetics, Human Studies, Molecular/Cellular, Neurobiology


2023 May 01

Mol Cell Neurosci


Epigenomic profiling of mouse nucleus accumbens at single-cell resolution.


Bhatia P, Yang L, Luo JXJ, Xu M, Renthal W


The nucleus accumbens (NAc) is a key brain region involved in reward processing and is linked to multiple neuropsychiatric conditions such as substance use disorder, depression, and chronic pain. Recent studies have begun to investigate persistent changes in NAc gene expression at a single-cell resolution, however, our understanding of the cellular heterogeneity of the NAc epigenomic landscape remains limited. In this study, we utilize single-nucleus assay for transposase-accessible chromatin using high-throughput sequencing (snATAC-seq) to map cell-type-specific differences in chromatin accessibility in the NAc. Our findings not only reveal the transcription factors and putative gene regulatory elements that may contribute to these cell-type-specific epigenomic differences but also provide a valuable resource for future studies investigating epigenomic changes that occur in neuropsychiatric disorders.