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Improving the Management of Postdural Puncture Headache-An International Clinical Guideline and Call for Better Evidence.

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Defining Comprehensive Disease Control for use as a Treatment Target for Ulcerative Colitis in Clinical Practice: International Delphi Consensus Recommendations.

Treatment of ulcerative colitis (UC) requires a patient-centric, definition of comprehensive disease control that considers improvements in aspects not typically captured by classical landmark trial endpoints. In an international initiative […]

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An Update on Temporomandibular Disorders (TMDs) and Headache.

To provide an overview and highlight recent updates in temporomandibular disorders (TMDs) and their comorbidity with headache disorders regarding pathophysiology and management.

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Zinc deficiency disrupts pain signaling promoting nociceptive but not inflammatory pain in mice.

Zinc (Zn) is an essential micronutrient involved in the physiology of nervous system and pain modulation. There is little evidence for the role of nutritional Zn alternations to the onset […]

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Patient experience of spontaneous intracranial hypotension (SIH): qualitative interviews for concept elicitation.

Spontaneous intracranial hypotension (SIH) is an underdiagnosed and debilitating condition caused by a spinal cerebrospinal fluid (CSF) leak. Although SIH can lead to substantial morbidity and disability, little data exists […]

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Hyperbaric oxygen therapy for late radiation tissue injury.

This is the third update of the original Cochrane Review published in July 2005 and updated previously in 2012 and 2016. Cancer is a significant global health issue. Radiotherapy is […]

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Photophobia Contributes to Migraine-Associated Disability and Reduced Work Productivity: Results From the American Registry for Migraine Research (ARMR).

Photosensitivity, often called “photophobia” in the migraine literature, is a common and bothersome symptom for most people during their migraine attacks. This study aimed to investigate the association of photophobia […]

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Occupational mechanical exposures as risk factor for chronic low-back pain: a systematic review and meta-analysis.

The association between occupational mechanical exposures and low-back pain (LBP) has been studied in several systematic reviews. However, no systematic review addressing chronic LBP exists. The aim of this systematic […]

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Role of Cav2.3 (R-type) Calcium Channel in Pain and Analgesia: A Scoping Review.

Voltage-gated calcium channels (VGCCs) play an important role in pain development and maintenance. As Cav2.2 and Cav3.2 channels have been identified as potential drug targets for analgesics, the participation of […]

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Interleukin-17: a putative novel pharmacological target for pathological pain.

Pathological pain imposes a huge burden on the economy and the lives of patients. At pre- sent, drugs used for the treatment of pathological pain have only modest efficacy and […]

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