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Exploratory evaluation of spinal cord stimulation with dynamic pulse patterns: a promising approach to improve stimulation sensation, coverage of pain areas, and expected pain relief.

The societal burden of chronic pain and the contribution-in-part to the opioid crisis, is a strong motivation to improve and expand non-addictive treatments, including spinal cord stimulation (SCS). For several […]

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Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity.

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to healthy controls (HCs) to explore the […]

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Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression.

The comorbid relationship between migraine and depression has been well recognized, but its underlying pathophysiology is unclear. Here, we aimed to explore the structural changes of the amygdala and the […]

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Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain.

Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which […]

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Ultrahigh frequency transcutaneous electrical nerve stimulation for neuropathic pain alleviation and neuromodulation.

A challenging complication in patients with peripheral compressive neuropathy is neuropathic pain. Excessive neuroinflammation at the injury site worsens neuropathic pain and impairs function. Currently, non-invasive modulation techniques like transcutaneous […]

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High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain.

The number of patients with chronic pain continues to increase against the background of an ageing society and a high incidence of various epidemics and disasters. One factor contributing to […]

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SOMATOSENSORY PROFILING OF PATIENTS WITH CLUSTER HEADACHE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

The objectives were 1) to synthesize Quantitative Sensory Testing results in Cluster Headache (CH) patients and to identify somatosensory differences from healthy subjects (HS) and 2) between symptomatic and asymptomatic […]

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Primary Headache Associated with Sexual Activity: A Review of the Literature.

This review summarizes the evolution in diagnosis, evaluation, and treatment of primary headache associated with sexual activity (PHASA).

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Pain coping, multidisciplinary care, and mHealth: Patients’ views on managing advanced cancer pain.

Pain is common among people with advanced cancer. While opioids provide significant relief, incorporating psycho-behavioral treatments may improve pain outcomes. We examined patients’ experiences with pain self-management and how their […]

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Effects of Embodiment in Virtual Reality for Treatment of Chronic Pain: Pilot Open-Label Study.

Chronic pain has long been a major health burden that has been addressed through numerous forms of pharmacological and nonpharmacological treatment. One of the tenets of modern medicine is to […]

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