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Despite affecting 2-4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive […]
Learn More >Sleep disturbance is a key symptom of fibromyalgia and a risk factor for chronic widespread pain. This systematic review and meta-analysis aims to assess the effectiveness of pharmacological treatments and […]
Learn More >Maladaptive brain plasticity has been reported in chronic pain (CP) conditions, though it remains unclear if there are common alterations across pathologies. Therefore, we systematically synthesized literature comparing resting-state functional […]
Learn More >Chronic headache is a common complication after mild traumatic brain injury (mTBI), which affects close to 70 million individuals annually worldwide. This study aims to test the utility of a […]
Learn More >Transdermal delivery is one of the most recent modes of administration studied due to several shortfalls observed for intra-venous, and oral drug administrations. Among, microneedle-based transdermal delivery is the popular […]
Learn More >Surgical nerve injuries lead to persistent neuropathic pain (NP) in up to 30% of patients. Among many other factors, polymorphisms in the human leukocyte antigen (HLA) genes have been suggested […]
Learn More >In celiac disease (CeD), dietary gluten serves as the driver for a comparatively well characterized small bowel mucosal immune response that generally results in small bowel mucosal villous atrophy and […]
Learn More >The potential contribution of intimate partner violence (IPV) to the development of neuropathic pain (NP) is not fully elucidated. Therefore, this study aimed to describe self-reported IPV in patients with […]
Learn More >Trigeminal neuralgia (TN) is a chronic pain condition characterized by severe, electric shock-like pain in one or more branches of the trigeminal nerve. Even though neuroimaging studies have highlighted alterations […]
Learn More >Knee osteoarthritis (OA), a degenerative joint disease, causes pain and reduced activity levels, with prevalence increasing with age. Knee OA is recognized as a “joint organ disease,” where interactions between […]
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