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Long term outcomes of occipital nerve stimulation.

Occipital nerve stimulation (ONS) has been investigated as a potential treatment for disabling headaches and has shown promise for disorders such as chronic migraine and cluster headache. Long term outcomes […]

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Rodent models of postherpetic neuralgia: How far have we reached?

Induced by varicella zoster virus (VZV), postherpetic neuralgia (PHN) is one of the common complications of herpes zoster (HZ) with refractory pain. Animal models play pivotal roles in disclosing the […]

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The role of the salience network in cognitive and affective deficits.

Analysis and interpretation of studies on cognitive and affective dysregulation often draw upon the network paradigm, especially the Triple Network Model, which consists of the default mode network (DMN), the […]

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A scoping review on the availability and utilization of essential opioid analgesics in Sub-Saharan Africa.

Management of acute, post-operative, and chronic pain requires access to and availability of opioids. While often oversupplied in high-income countries, significant shortages exist in low- and middle-income countries. We conducted […]

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Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis.

Psoriasis vulgaris (PV) is a chronic skin inflammatory disease and characterized by aberrant epidermal hyperplasia. The molecule eukaryotic initiation factor (eIF) 4E controls translation initiation of certain protein synthesis and […]

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Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity.

Pain and obesity, as well as their associated impairments, are major health concerns. Understanding the relationship between the two is the focus of a growing body of research. However, early […]

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Factors Influencing Parental Decision-making Regarding Analgesia for Children with Musculoskeletal Injury-related Pain: A Qualitative Study.

To explore and understand parental decision-making relating to acute pain management for their children presenting to the emergency department.

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Identification of an essential spinoparabrachial pathway for mechanical itch.

The sensation of itch is a protective response that is elicited by either mechanical or chemical stimuli. The neural pathways for itch transmission in the skin and spinal cord have […]

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Early life iron deficiency persistently alters nociception in developing mice.

Clinical association studies have identified early life iron deficiency (ID) as a risk factor for the development of chronic pain. While preclinical studies have shown that early life ID persistently […]

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Motor corticospinal excitability abnormalities differ between distinct chronic low back pain syndromes.

It is not known whether cortical plastic changes reported in low-back pain (LBP) are present in all etiologies of LBP. Here we report on the assessment of patients with three […]

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