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Interpersonal dynamics in chronic pain: The role of partner behaviors and interactions in chronic pain adjustment.

Chronic pain affects one-third of adults globally, leading to significant disability and healthcare costs. This review highlights the role of interpersonal processes in chronic pain adjustment, focusing on how partner […]

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Mapping cell diversity and dynamics in inflammatory temporomandibular joint osteoarthritis with pain at single-cell resolution.

Temporomandibular joint (TMJ) osteoarthritis with pain is a highly prevalent disorder affecting patients’ quality of life. A comprehensive understanding of cell type diversity and its dynamics in painful TMJ osteoarthritis […]

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Reframing pain care: An equity lens on psychosocial and behavioural interventions.

This review critically examines psychosocial and behavioural interventions for chronic pain through an equity lens. We interrogate relevant literature drawing on three key organising principles; justice, access, and knowledge, to […]

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Investigating Brain Structure and Functional Alterations in the Transition from Acute to Chronic Neck Pain: A Resting-State fMRI Study.

The objective of this research is to delve into the central pathological mechanisms involved in the transformation from acute to chronic pain.

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The future of topical JAK inhibitors in the treatment of atopic dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory skin condition, rising in prevalence and significantly impacting quality of life. Janus kinase (JAK) inhibitors are small molecules targeting the JAK-STAT signaling pathway, […]

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Relative risks of adverse effects across different opioid agonist treatments-A systematic review and meta-analysis.

Opioid agonist treatment (OAT) is established for opioid use disorder, but limited data on adverse effects exist. We aimed to review relative risks of adverse effects across opioid agonists.

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Characterisation of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model.

Many rheumatoid arthritis (RA) patients continue to experience persistent pain even after successful management of joint inflammation. Clinical data indicate that RA patients treated with the JAK inhibitor baricitinib consistently […]

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Discovery of Novel Pain Regulators Through Integration of Cross-Species High-Throughput Data.

Chronic pain is an impeding condition that affects day-to-day life and poses a substantial economic burden, surpassing many other health conditions. This study employs a cross-species integrated approach to uncover […]

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Impact of Psychological Resilience on the Fear of Pain and Activity Recovery in Postsurgical Patients: Observational Cohort Study.

The fear of pain (FOP) and fear avoidance belief (FAB) play a crucial role in the occurrence and development of chronic pain. However, the dynamics of these factors in postsurgical […]

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Deletion of β-arrestin 2 in mice affects kappa opioid receptor-mediated behaviors depending on sex, ovariectomy status, and behavioral endpoints.

We previously demonstrated that in a mouse line expressing a kappa opioid receptor (KOR) mutant with all the four phosphorylation sites mutated to alanines (K4A) the selective KOR agonist U50,488H […]

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