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Papers of the Week


Papers: 8 Feb 2025 - 14 Feb 2025


2025 Feb 09


Expert Opin Pharmacother


39924470

The future of topical JAK inhibitors in the treatment of atopic dermatitis.

Authors

Mazgaj J, Kotewicz M, Jaworek A, Szepietowski JC

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin condition, rising in prevalence and significantly impacting quality of life. Janus kinase (JAK) inhibitors are small molecules targeting the JAK-STAT signaling pathway, responsible for immune response and cell proliferation. Therapy with topical JAK inhibitors (JAKinibs) improves AD itch and skin lesions and is well tolerated with no major side effects, making it an interesting novel therapy for AD.