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Papers of the Week
Characterisation of the antinociceptive effect of baricitinib in the collagen antibody-induced arthritis mouse model.
Authors
Simon N, Rudjito R, Moll L, Sandor K, Vazquez-Mora JA, Kurtović Z, Kuliszkiewicz A, Urbina CEM, Arvidsson SD, Mendoza-Sánchez E, López-Delgado GE, Luo Q, Deng Q, Martínez AM, Gerwien JG, Karila P, Krishnan V, Jiménez-Andrade JM, Svensson CIAbstract
Many rheumatoid arthritis (RA) patients continue to experience persistent pain even after successful management of joint inflammation. Clinical data indicate that RA patients treated with the JAK inhibitor baricitinib consistently achieve pain relief that cannot be entirely attributed to its anti-inflammatory effects. In this study, we investigated the antinociceptive properties of baricitinib using the collagen antibody-induced arthritis (CAIA) model in which mechanical hypersensitivity persists long after resolution of joint inflammation.