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Review

Home / Publications / Pain Research Forum / Papers of the Week / Review
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NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain – Emphasis on microRNAs (miRNAs) as important regulators.

Neuropathic pain is caused by the lesion or disease of the somatosensory system and can be initiated and/or maintained by both central and peripheral mechanisms. Nerve injury leads to neuronal […]

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Mini-Review: Enteric Glial Cell Reactions to Inflammation and Potential Therapeutic Implications for GI Diseases, Motility Disorders and Abdominal Pain.

Enteric glial cells are emerging as critical players in the regulation of intestinal motility, secretion, epithelial barrier function, and gut homeostasis in health and disease. Enteric glia react to intestinal […]

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IL-33/ST2 signaling in pain and itch: Cellular and molecular mechanisms and therapeutic potentials.

Pain is a cardinal feature of many diseases. Chronic pain poses heavy burdens to the suffering patients, both physically and mentally. However, current mainstream medications for chronic pain, including opioids, […]

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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Occipital Nerve Stimulation for the Treatment of Patients With Medically Refractory Occipital Neuralgia: Update.

The Guidelines Task Force conducted a systematic review of the relevant literature on occipital nerve stimulation (ONS) for occipital neuralgia (ON) to update the original 2015 guidelines to ensure timeliness […]

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A systematic literature review on the role of glial cells in the pathomechanisms of migraine.

The pathomechanisms underlying migraine are intricate and remain largely unclear. Initially regarded as a neuronal disorder, migraine research primarily concentrated on understanding the pathophysiological changes within neurons. However, recent advances […]

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Ox-inflammasome involvement in neuroinflammation.

Neuroinflammation plays a crucial role in the onset and the progression of several neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to post-COVID 19 neurological manifestations. Inflammasomes are cytosolic […]

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Notch signaling pathway: a new target for neuropathic pain therapy.

The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors […]

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Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions.

In this review, the latest insights into habituation to pain in chronic pain are summarized. Using a systematic search, results of studies on the evidence of habituation to (experimental) pain […]

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The Biology of Chronic Pain and Its Implications for Pain Neuroscience Education: State of the Art.

Pain is an individualized experience for the person suffering from chronic pain. Significant strides have been made in the last few decades in understanding various biological changes that coincide with […]

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Assessment of Pain and Inflammation in Domestic Animals Using Infrared Thermography: A Narrative Review.

Pain assessment in domestic animals has gained importance in recent years due to the recognition of the physiological, behavioral, and endocrine consequences of acute pain on animal production, welfare, and […]

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