Browse by Audience
Recent evidence suggests that Vitamin D may interact with the epigenome and play a role in the pain experience. In order for proper functioning to occur, there must be an […]
Learn More >By endowing light control of neuronal activity, optogenetics and photopharmacology are powerful methods notably used to probe the transmission of pain signals. However, costs, animal handling and ethical issues have […]
Learn More >Brachial plexus avulsion (BPA) injury develops frequent and intense neuropathic pain, involving in both peripheral and central nervous systems. The incidence of anxiety or depression caused by BPA-induced neuropathic pain […]
Learn More >μ-Conotoxin KIIIA, a selective blocker of sodium channels, has strong inhibitory activity against several Na isoforms, including Na1.7, and has potent analgesic effects, but it contains three pairs of disulfide […]
Learn More >Trigeminal neuralgia is a common chronic maxillofacial neuropathic pain disorder, and voltage-gated sodium channels (VSGCs) are likely involved in its pathology. Prior studies report that pituitary adenylate cyclase-activating polypeptide (PACAP), […]
Learn More >The growing opioid use and overdose crisis in the US is closely related to the abuse of pain medications. Particularly for postoperative pain (POP), ~ 310 million major surgeries are performed globally […]
Learn More >Ca imaging can be used as a proxy for cellular activity, including action potentials and various signaling mechanisms involving Ca entry into the cytoplasm or the release of intracellular Ca […]
Learn More >Chronic pain is a significant problem that afflicts individuals and society, and for which the current clinical treatment is inadequate. In addition, the neural circuit and molecular mechanisms subserving chronic […]
Learn More >Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain. Sex differences […]
Learn More >It is well established that temperature affects the functioning of almost all biomolecules and, consequently, all cellular functions. Here, we show how temperature variations within a physiological range affect primary […]
Learn More >