I am a
Home I AM A Search Login

Basic Science

Share this

An amygdala-to-cingulate cortex circuit for conflicting choices in chronic pain.

Chronic pain is a complex experience with multifaceted behavioral manifestations, often leading to pain avoidance at the expense of reward approach. How pain facilitates avoidance in situations with mixed outcomes is […]

Learn More >

Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease.

Pain is the most common symptom experienced by patients with sickle cell disease (SCD) throughout their lives and is the main cause of hospitalization. Despite the progress that has been […]

Learn More >

Evaluation of trans- and cis-4-[18F]fluorogabapentin for brain PET imaging.

Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, focal epilepsy and other neurological conditions. We […]

Learn More >

Disruption of Ordered Membrane Domains as a Mechanism Underlying Neuropathic Pain.

Cell membranes consist of heterogeneous lipid domains that influence key cellular processes, including signal transduction, endocytosis, and electrical excitability. The goal of this study was to assess the size of […]

Learn More >

Loss of ATP-sensitive channel expression and function decreases opioid sensitivity in a mouse model of type 2 diabetes.

During diabetes, β-cell dysfunction due to loss of potassium channels sensitive to ATP, known as K channels occurs progressively over time contributing to hyperglycemia. K channels are additionally present in […]

Learn More >

Preclinical study in a postoperative pain model to investigate the action of ketamine, lidocaine, and ascorbic acid in reversing fentanyl-induced, non-glutamate-dependent hyperalgesia.

Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon in which exposure to opioids can increase sensitivity to painful stimuli. Currently, several drugs have been used in an attempt to prevent OIH. […]

Learn More >

Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles.

Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood.

Learn More >

The Capsaicin Binding Affinity of Wild-Type and Mutant TRPV1 Ion Channels.

Vanilloids such as capsaicin and resiniferatoxin (RTX) are highly selective and potent activators for TRPV1, a nociceptor for heat and pain perception. However, the intrinsic vanilloid binding affinity, key for […]

Learn More >

A cholinergic circuit that relieves pain despite opioid tolerance.

Chronic pain is a tremendous burden for afflicted individuals and society. Although opioids effectively relieve pain, significant adverse outcomes limit their utility and efficacy. To investigate alternate pain control mechanisms, […]

Learn More >

Cryo-EM structures of human GPR34 enable the identification of selective antagonists.

GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report a cryo-electron microscopy (cryo-EM) structure of GPR34 […]

Learn More >