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You Feel What You Eat: ω-6 Polyunsaturated Fatty Acids Drive Painful Neuropathy in Mice

In The Physiology of Taste, a classic first published in 1825, Jean Anthelme Brillat-Savarin wrote: “Tell me what you eat and I will tell you what you are.”   That […]

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Nociceptors Regulate the Innate and Adaptive Immune Response to Viral Infection

Researchers know that infectious agents can lead to pain either through direct or indirect activation of nociceptors. Nociceptors then release neuropeptides from their peripheral terminals, which in turn can influence […]

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The Vitamin D-Opioid Addiction Link

Millions of people continue to misuse opioids each year, pointing to the need for an improved understanding of the determinants of these painkillers' detrimental effects. A recent study now proposes […]

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Substituting Cannabidiol for Pain Medications: An Experiment Well Underway in Fibromyalgia Patients

Fibromyalgia is a common condition characterized by widespread pain and accompanying symptoms like fatigue, sleep problems, and cognitive issues. The few medications available to treat fibromyalgia, including the antidepressants duloxetine […]

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The Naked Mole-Rat: A Curious Creature With Many Lessons for Pain Researchers

Of all the rodents used for pain research, the naked mole-rat (Heterocephalus glaber) certainly stands out. This African animal, which can live for over 30 years and is resistant to […]

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Thinking Outside of the Box When Communicating About Pain

Editor’s note: The 2021 Australian Pain Society 41st Annual Scientific Meeting was held virtually April 19-20. This report summarizes a session at the meeting that argued for outside-of-the-box thinking when […]

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Sinking the Inflammarafts in Spinal Microglia Calms the Storm of Neuropathic Pain

Pain researchers are well aware that microglia play a critical role in pain sensitization after nerve injury. Known as the immune cells of the central nervous system, microglia drive the […]

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Responding Empathetically to Patient Distress

People seeking treatment for pain are often emotionally distressed. It is important that clinicians recognize and respond appropriately to this distress that can shape patients’ experiences and expectations of care, […]

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An Objective Measure of Itch

A wide variety of medical conditions can lead to itchy skin. One of those conditions, atopic dermatitis (eczema), affects 10 million children in the US alone. Yet itch is a […]

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Octopuses Have Affective Pain Experience

While it is generally recognized that invertebrates experience the nociceptive aspects of pain, in the form of reflexive responses to noxious stimuli, there has been much debate about whether they […]

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