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How Does Pain Lead to a Decrease in Brain Dopamine Levels?

In addition to reward and motivational processing, dopamine (DA) dysfunction is also associated with many chronic pain conditions. It is known that pain reduces the activity of DA neurons in […]

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The Most Popular Content of PRF in 2021

The year 2021 required pain researchers to continue to adapt to the myriad of challenges presented by the ongoing pandemic. Through the increased utilization of hybrid approaches, interdisciplinary collaboration, creativity, […]

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STING Immunotherapy: A Complementary Approach to Treating Bone Cancer Pain

Cancer is a leading cause of death in North America, and extracts a highly damaging personal and economic toll on those who suffer from it. Many common cancers, including those […]

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Nonpeptidergic Neurons Work to Suppress Mast Cells in the Skin

Research published in Cell on April 15, 2021, found that a specific subset of neurons, MrgprD-expressing neurons, suppress mast cell hyperresponsiveness in the skin and work to maintain skin homeostasis. […]

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Sex-Specific Differences in Pain Mechanism

A plethora of epidemiological studies demonstrate that chronic pain conditions are more common in women than in men. Women are also at a greater risk for developing common chronic pain […]

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What Do Patients Want to Know About Pain?

Pain education is an integral part of interventions to alleviate pain, with the goal of helping people with pain reconceptualize what pain actually is. Several campaigns such as Pain Revolution […]

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Dose Tapering in Patients Prescribed Long-Term Opioids: More Harm Than Good?

Opioids are a complex and controversial topic in the pain field. Debate surrounding use of these drugs has intensified over the last decade because of increases in opioid-related morbidity and […]

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The Pain Research Forum Welcomes Gregory Carbonetti and Thanks Neil Andrews for His Outstanding Service

Since joining PRF in February 2012, Neil Andrews has devoted himself to the development and continued excellence of the Pain Research Forum. PRF, which began as a joint project between […]

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David Julius and Ardem Patapoutian Awarded the 2021 Nobel Prize in Physiology or Medicine

On October 4, 2021, the Nobel Assembly at Karolinska Institutet jointly awarded David Julius and Ardem Patapoutian the Nobel Prize in Physiology or Medicine for their independent discoveries of receptors […]

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Antibodies From Patients Cause Fibromyalgia Symptoms in Mice

Fibromyalgia syndrome (FMS) is one of the most common chronic pain conditions, and yet the underlying mechanisms driving it have remained elusive. Previous work has started to build a case […]

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