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Papers of the Week

2021 Apr 24

Curr Rheumatol Rep



Involvement of Macrophages and Spinal Microglia in Osteoarthritis Pain.


Pan T-T, Pan F, Gao W, Hu S-S, Wang DI
Curr Rheumatol Rep. 2021 Apr 24; 23(5):29.
PMID: 33893883.


Chronic pain in osteoarthritis (OA) is characterized by pain sensitization, which involves both peripheral and central mechanisms. Studies suggest synovial macrophage and spinal microglia are implicated in pain sensitization in OA. We, therefore, reviewed the evidence of whether synovial macrophage and spinal microglia facilitated pain sensitization at diverse levels and how this event occurred in OA.