I am a
Home I AM A Search Login

Papers of the Week


2021 Apr 24


Curr Rheumatol Rep


23


5

Involvement of Macrophages and Spinal Microglia in Osteoarthritis Pain.

Authors

Pan T-T, Pan F, Gao W, Hu S-S, Wang DI
Curr Rheumatol Rep. 2021 Apr 24; 23(5):29.
PMID: 33893883.

Abstract

Chronic pain in osteoarthritis (OA) is characterized by pain sensitization, which involves both peripheral and central mechanisms. Studies suggest synovial macrophage and spinal microglia are implicated in pain sensitization in OA. We, therefore, reviewed the evidence of whether synovial macrophage and spinal microglia facilitated pain sensitization at diverse levels and how this event occurred in OA.