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Opioid use disorder (OUD) is a rising public health crisis, impacting millions of individuals and families worldwide. Anesthesiologists can play a key role in improving morbidity and mortality around the […]
Learn More >The pharmacological management of musculoskeletal pain starts with NSAIDs, followed by weak or strong opioids until the pain is under control. However, the treatment outcome is usually unsatisfying due to […]
Learn More >Cyclin-dependent kinase (CDK) 4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have revolutionized the treatment of metastatic breast carcinoma. They currently form the first-line treatment, in combination with endocrine agents, for the […]
Learn More >Pathological pain imposes a huge burden on the economy and the lives of patients. At pre- sent, drugs used for the treatment of pathological pain have only modest efficacy and […]
Learn More >Calcitonin gene-related peptide (CGRP) is involved in migraine pathophysiology. CGRP can signal through two receptors. The canonical CGRP receptor comprises the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 […]
Learn More >Multiple approaches, including cryo-EM, indicate that the anesthetics etomidate and propofol modulate α1β2/3γ2 GABA receptors by binding in overlapping transmembrane inter-subunit sites near βM286 and αL232 sidechains. High precision approaches […]
Learn More >Brainstem areas involved in descending pain modulation are crucial for the analgesic actions of opioids. However, the role of opioids in these areas during tolerance, opioid-induced hyperalgesia (OIH), and in […]
Learn More >Current treatments for chronic pain are inadequate. Here, we provide an update on the new therapeutic strategies that target dorsal root ganglia (DRGs) in the peripheral nervous system for a […]
Learn More >Postdural puncture headache (PDPH) can follow unintentional dural puncture during epidural techniques or intentional dural puncture during neuraxial procedures such as a lumbar puncture or spinal anesthesia. Evidence-based guidance on […]
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An answered call for aid? Cannabinoid clinical framework for the opioid epidemic.
The opioid crisis continues in full force, as physicians and caregivers are desperate for resources to help patients with opioid use and chronic pain disorders find safer and more accessible […]
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