Browse by Audience
The co-occurrence of migraine and glycemic traits has long been reported in observational epidemiological studies, but it has remained unknown how they are linked genetically. We used large-scale GWAS summary […]
Learn More >The mechanism underlying irritable bowel syndrome (IBS), a common disease with hyperalgesia, remains elusive. The spinal cholinergic system is involved in pain modulation, but its role in IBS is unknown.
Learn More >Fragile X Mental Retardation Protein (FMRP) regulates activity-dependent RNA localization and local translation to modulate synaptic plasticity throughout the central nervous system. Mutations in the FMR1 gene that hinder or […]
Learn More >Inward-rectifying K channel 4.1 (Kir4.1), which regulates the electrophysiological properties of neurons and glia by affecting K homeostasis, plays a critical role in neuropathic pain. Metabotropic glutamate receptor 5 (mGluR5) […]
Learn More >Evaluate outcomes of genicular nerve chemical neurolysis (GChN) in a real-world population with chronic knee pain.
Learn More >Prurigo nodularis (PN) is an extremely pruritic, chronic inflammatory skin disease. Little is known about systemic inflammation in PN.
Learn More >Depression and thermal hypersensitivity share pathogenic features and symptomology, but their pathophysiologic interactions have not been fully eluidated. Dopaminergic systems in the ventrolateral periaqueductal gray and dorsal raphe nucleus have […]
Learn More >In mammals, pain is regulated by the combination of an ascending stimulating and descending inhibitory pain pathway. It remains an intriguing question whether such pain pathways are of ancient origin […]
Learn More >Spreading depolarization (SD), the underlying mechanism of migraine aura, may trigger the opening of the Pannexin-1 (Panx1) pore to sustain the cortical neuroinflammatory cascades involved in the genesis of headache. […]
Learn More >Post-burn pruritus and neuropathic pain significantly affect the quality of life of affected individuals in several domains including psychosocial well-being, sleep and general impairment in activities of daily living. Whilst […]
Learn More >