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μ-Conotoxin KIIIA, a selective blocker of sodium channels, has strong inhibitory activity against several Na isoforms, including Na1.7, and has potent analgesic effects, but it contains three pairs of disulfide […]
Learn More >Persistent pain can be managed with opioids, but their use is limited by the onset of tolerance. Ultramicronized -palmitoylethanolamine (PEA) in vivo delays morphine tolerance with mechanisms that are still […]
Learn More >The cytokine oncostatin M (OSM) is regarded as a critical mediator in various inflammatory responses. While the gaseous signaling molecule hydrogen sulfide (HS) plays a role in a variety of […]
Learn More >The highly dynamic changes in microglia necessary to achieve a rapid neuroinflammatory response require a supply of energy from mitochondrial respiration, which leads to the accumulation of unfolded mitochondrial proteins. […]
Learn More >Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that have started to revolutionize medical science in terms of understanding disease, testing pharmacologically active compounds, and offering novel ways to […]
Learn More >New sets of ibuprofen and indomethacin conjugates comprising triazolyl heterocycle were synthesized via click chemistry, adopting an optimized protocol through the molecular hybridization approach affording the targeted agents in good […]
Learn More >Damage to intervertebral discs (IVD) can lead to chronic pain and disability, and no current treatments can fully restore their function. Some non-surgical treatments have shown promise; however, these approaches […]
Learn More >Despite the high prevalence of chronic pain as a disease in our society, there is a lack of effective treatment options for patients living with this condition. Gene therapies using […]
Learn More >Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 […]
Learn More >Acute and chronic pain is often treated with opioids despite the negative side effects of constipation, physical dependence, respiratory depression, and overdose. The misuse of opioid analgesics has given rise […]
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