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Reduction of Systemic Exposure and Side Effects by Intra-articular Injection of Anti-inflammatory Agent for Osteoarthritis: What is the Safer Strategy?

Osteoarthritis (OA) is a chronic degenerative joint disease associated with pain, inflammation, and cartilage degradation. However, no current treatment can effectively halt the progression of the disease. Therefore, the use […]

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Differential target multiplexed spinal cord stimulator: a review of preclinical/clinical data and hardware advancement.

Spinal cord stimulation (SCS) is an effective neuromodulation technique for treating chronic neuropathic pain. Recent rapid growth in understanding its mechanism has led to the development of glial cell-based differential […]

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Muscle synergy patterns as altered coordination strategies in individuals with chronic low back pain: a cross-sectional study.

Chronic low back pain (CLBP) is a highly prevalent disease with poorly understood underlying mechanisms. In particular, altered trunk muscle coordination in response to specific trunk tasks remains largely unknown.

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First-in-human phase I studies of YJ001 spray applied to local skin in healthy subjects and patients with diabetic neuropathic pain.

The study aimed to investigate the safety, pharmacokinetics (PK), and efficacy of YJ001 spray, a candidate drug for diabetic neuropathic pain (DNP) therapy.

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The use of clinical scales and PROMs in headache disorders and migraine, summarizing their dissemination and operationalization.

Measurements are an essential aspect of scientific research. This review will present clinical scales and patient-reported outcome measures (PROMs) for headache disorders and migraine that have been endorsed by the […]

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Real-world experience with secukinumab in the entire axial spondyloarthritis spectrum.

Secukinumab is a biologic disease-modifying antirheumatic drug (bDMARD) that has demonstrated efficacy in the treatment of axial spondyloarthritis (axSpA, i.e., ankylosing spondylitis and non-radiographic axSpA) across various clinical trials. However, […]

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Pruritogenic molecules in the skin of patients with dermatomyositis.

Pruritus is a common excruciating symptom in systemic autoimmune diseases such as dermatomyositis (DM) but the pathogenesis is not fully understood. We intended to investigate the targeted expression analysis of […]

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A randomised sham-controlled study evaluating rTMS analgesic efficacy for postherpetic neuralgia.

Postherpetic neuralgia (PHN) is a refractory neuropathic pain condition in which new treatment options are being developed. Repetitive transcranial magnetic stimulation (rTMS) may have the potential to reduce pain sensations […]

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Decision-making impairment under ambiguity but not under risk may underlie medication overuse in patients with chronic migraine.

To explore whether patients with chronic migraine and medication overuse headache (CM + MOH) present with decision-making deficit.

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Evaluation of Auditory Temporal Discrimination Thresholds in Migraine Patients.

Although vestibular migraine is well defined, the effects of migraine on the auditory system have not been clearly identified yet. The aim of this study was to determine the effect […]

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