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Papers of the Week
Pruritogenic molecules in the skin of patients with dermatomyositis.
Authors
Vincze A, Herczeg-Lisztes E, Szabó K, Béldi TG, Nagy-Vincze M, Pór Á, Varga J, Dankó K, Biró T, Tóth BI, Griger ZAbstract
Pruritus is a common excruciating symptom in systemic autoimmune diseases such as dermatomyositis (DM) but the pathogenesis is not fully understood. We intended to investigate the targeted expression analysis of candidate molecules involved in the development of pruritus in lesional vs. non-lesional skin samples of patients affected with active DM. We looked for correlations between the investigated pruriceptive signaling molecules, disease activity, and itching sensation of DM patients.