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Human Studies

Home / Publications / Pain Research Forum / Papers of the Week / Human Studies
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Do both the research community and the general public share an interest in the sleep-pain relationship, and do they influence each other?

Chronic pain and sleep disturbance bidirectionally influence each other in a negative spiral. Although this academic knowledge is known by researchers, it is imperative to bridge it over to the […]

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Digital Biomarker Applications Across the Spectrum of Opioid Use Disorder.

Opioid use disorder (OUD) is one of the most pressing public health problems of the past decade, with over eighty thousand overdose related deaths in 2021 alone. Digital technologies to […]

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Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies.

Tendinopathy is a medical condition that includes a spectrum of inflammatory and degenerative tendon changes caused by traumatic or overuse injuries. The pathological mechanism of tendinopathy has not been well […]

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Long-term analgesic effect of trans-spinal direct current stimulation compared to non-invasive motor cortex stimulation in complex regional pain syndrome.

The aim of the present study was to compare the analgesic effect of motor cortex stimulation using high-frequency repetitive transcranial magnetic stimulation or transcranial direct current stimulation and transcutaneous spinal […]

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Long-Term Opioid Use and Dementia Risk in Patients With Chronic Pain.

This study aimed to investigate the association between long-term opioid use and the risk of dementia in patients with chronic pain.

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The effect of erenumab on brain network function in episodic migraine patients: a randomized, placebo-controlled clinical trial (RESET BRAIN).

We aimed to explore whether erenumab, a monoclonal antibody targeting the calcitonin gene-related peptide receptor, could exert a central effect on brain network function in migraine, and investigate the persistence […]

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Immediate systemic neuroimmune responses following spinal mobilisation and manipulation in people with non-specific neck pain: a randomised placebo-controlled trial.

Spinal mobilisation/manipulation is a common intervention for spinal pain, yet the working mechanisms are largely unknown. A randomised placebo-controlled trial was conducted to (1) compare the immediate neuroimmune responses following […]

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BurstDR spinal cord stimulation rebalances pain input and pain suppression in the brain in chronic neuropathic pain.

Chronic pain is processed by at least three well-known pathways, two pain provoking pathways including a medial ‘suffering’ and lateral ‘painfulness’ pathway. A third descending pain pathway modulates pain but […]

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Chronic Pain Management in Sickle Cell Disease: A Systematic Scoping Review of Controlled Trials.

Existing treatment for chronic pain in sickle cell disease (SCD) is opioid-dependent, which is ineffective and carries risks. We conducted a scoping literature review to assess the size and scope […]

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Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis.

Some probiotics may be beneficial in irritable bowel syndrome (IBS), but differences in species and strains used, as well as endpoints reported, have hampered attempts to make specific recommendations as […]

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