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General anesthesia alters CNS and astrocyte expression of activity-dependent and activity-independent genes.

General anesthesia represents a common clinical intervention and yet can result in long-term adverse CNS effects particularly in the elderly or dementia patients. Suppression of cortical activity is a key […]

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Which headache disorders can be diagnosed concurrently? An analysis of ICHD3 criteria using prime encoding system.

Real-life headache presentations may fit more than one ICHD3 diagnosis. This project seeks to exhaustively list all logically consistent “co-diagnoses” according to the ICHD3 criteria. We limited our project to […]

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Five Reasons Why Some Herniated Intervertebral Discs are Painless.

Herniated intervertebral discs (HIVDs) can cause lower back pain and leg pain, but not all cases are painful. We suggest five potential reasons for painless HIVDs. First, when inflammation resolves […]

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Calcitonin gene-related peptide causes migraine aura.

Although the involvement of calcitonin gene-related peptide (CGRP) in migraines is well-established, its specific role in investigating the aura phase, which often precedes the headache, remains largely unexplored. This study […]

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Investigating the relationship between sleep and migraine in a global sample: a Bayesian cross-sectional approach.

There is a bidirectional link between sleep and migraine, however causality is difficult to determine. This study aimed to investigate this relationship using data collected from a smartphone application.

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Split-face study to evaluate efficacy of global cryomodulation for reduction of pain and inflammation after nonablative fractional resurfacing.

Cryomodulation, or the delivery of controlled cooling to downregulate inflammatory processes in the skin, has been proposed to mitigate acute side effects following various dermatologic treatments. A new controlled cooling […]

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Real-World Clinical, Psychosocial, and Economic Burden of Atopic Dermatitis: Results From a Multicountry Study.

Atopic dermatitis (AD), a relapsing, inflammatory skin disease, is associated with pruritus that can negatively affect patients’ quality of life. Understanding the burden of AD is critical for informing and […]

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Improvement of morning headache in adults with obstructive sleep apnea after positive airway pressure therapy.

The aim of this study was to evaluate the association between obstructive sleep apnea and morning headache and to assess the improvement of morning headache following positive airway pressure therapy. […]

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The Ca channel ORAI1 is a regulator of oral cancer growth and nociceptive pain.

Oral cancer causes pain associated with cancer progression. We report here that the function of the Ca channel ORAI1 is an important regulator of oral cancer pain. was highly expressed […]

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Educating Nursing Students About Chronic Pain Management and Opioids: A Research Study.

Healthcare professionals’ knowledge of safe use of opioids for chronic pain management is critical in preventing opioid abuse and overdose. Undergraduate curricula of health professional schools, including undergraduate nursing programs, […]

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