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Papers of the Week

Papers: 2 Sep 2023 - 8 Sep 2023

Basic Science

Genetics, Human Studies, In Vitro Studies, Molecular/Cellular

Cancer Pain, Orofacial/Head Pain

2023 Sep 05

Sci Signal




The Ca channel ORAI1 is a regulator of oral cancer growth and nociceptive pain.


Son GY, Tu NH, Santi MD, Loya Lopez S, Souza Bomfim GH, Vinu M, Zhou F, Chaloemtoem A, Alhariri R, Idaghdour Y, Khanna R, Ye Y, Lacruz RS


Oral cancer causes pain associated with cancer progression. We report here that the function of the Ca channel ORAI1 is an important regulator of oral cancer pain. was highly expressed in tumor samples from patients with oral cancer, and ORAI1 activation caused sustained Ca influx in human oral cancer cells. RNA-seq analysis showed that ORAI1 regulated many genes encoding oral cancer markers such as metalloproteases (MMPs) and pain modulators. Compared with control cells, oral cancer cells lacking formed smaller tumors that elicited decreased allodynia when inoculated into mouse paws. Exposure of trigeminal ganglia neurons to MMP1 evoked an increase in action potentials. These data demonstrate an important role of ORAI1 in oral cancer progression and pain, potentially by controlling MMP1 abundance.