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Comparison of a One- versus Two-Week Treatment with Famciclovir Upon Reductions in Pain and Occurrence of Postherpetic Neuralgia in Herpes Zoster: A Randomized Open-Label Trial.

Herpes zoster (HZ) is an acute herpetic skin disease resulting from the varicella-zoster virus. Typically, this condition is treated with a one-week administration of antiviral drugs, including famciclovir, which can […]

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PACAP-PAC1 receptor inhibition is effective in opioid induced hyperalgesia and medication overuse headache models.

Opioids prescribed for pain and migraine can produce opioid-induced hyperalgesia (OIH) or medication overuse headache (MOH). We previously demonstrated that pituitary adenylate cyclase activating polypeptide (PACAP) is upregulated in OIH […]

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Genome-Wide Gene Expression Profiling Reveals the Direct Effect of Dienogest on Ovarian Endometriotic Stromal Cells.

Endometriosis affects up to 10% of women of reproductive age, causing dysmenorrhea, chronic pelvic pain, and infertility. The current key drug for endometriosis is dienogest, a progestin with high specificity […]

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Lifetime history of an anxiety or depression disorder and adherence to medications used for the acute treatment of migraine.

In this secondary analysis of mobile health headache diary data, we evaluated the relationship between adherence to medication used for the acute treatment of migraine and lifetime history of an […]

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Prolactin in headache and migraine: A systematic review of preclinical studies.

To systemically review preclinical studies investigating the implication of prolactin signaling in headache and migraine pathophysiology.

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OnabotulinumtoxinA effects on trigeminal nociceptors.

OnabotulinumtoxinA (onabotA) is approved globally for prevention of chronic migraine; however, the classical mechanism of action of onabotA in motor and autonomic neurons cannot fully explain the effectiveness of onabotulinumtoxinA […]

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Functional magnetic resonance imaging in migraine: A systematic review.

Migraine is a highly prevalent primary headache disorder. Despite a high burden of disease, key disease mechanisms are not entirely understood. Functional magnetic resonance imaging is an imaging method using […]

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Headache classification and automatic biomarker extraction from structural MRIs using deep learning.

Data-driven machine-learning methods on neuroimaging (e.g. MRI) are of great interest for the investigation and classification of neurological diseases. However, traditional machine learning requires domain knowledge to delineate the brain […]

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Oral Janus kinase inhibitors in the treatment of atopic dermatitis: A systematic review and meta-analysis.

Janus kinase (JAK) inhibitors are being evaluated as promising upcoming treatments for atopic dermatitis (AD).

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Small fiber neuropathy and intractable scalp pruritus in dermatomyositis patients.

Scalp pruritus is a common symptom in Dermatomyositis (DM) patients. There are indications that small nerve fibers neuropathy could be involved in this symptom, however the etiology of scalp pruritus […]

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