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Autologous mesenchymal stem cell transplantation for spinal fusion: 10 years follow-up of a phase I/II clinical trial.

Posterolateral spinal fusion is the standard surgical approach for patients with degenerative disc disease. In our previously published article, we reported a 5-years follow-up of a phase I/II clinical trial […]

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European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline.

The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.

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Treatment with delgocitinib cream improves itch, pain and other signs and symptoms of chronic hand eczema: Results from the Hand Eczema Symptom Diary in a phase IIb randomized clinical trial.

Measuring patient-reported outcomes is crucial to fully capture the burden of chronic hand eczema (CHE).

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A randomized controlled trial to examine the effect of the Pediatric Opioid Analgesia Self-Instruction System (PedOASIS) tool on pediatric hematology/oncology trainee education.

Many children with hematologic and oncologic diagnoses require opioids for management of pain, yet knowledge gaps persist among pediatric hematology/oncology (PHO) fellows.

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Increased iron deposition in nucleus accumbens associated with disease progression and chronicity in migraine.

Migraine is one of the world’s most prevalent and disabling diseases. Despite huge advances in neuroimaging research, more valuable neuroimaging markers are still urgently needed to provide important insights into […]

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Effect of transcutaneous electrical nerve stimulation on pain-related quantitative sensory tests in chronic musculoeskeletal pain and acute experimental pain: systematic review and meta-analysis.

This report provides a systematic review of the literature to analyze the effects of transcutaneous electrical nerve stimulation (TENS) on analgesia on sensitization measures, in studies with chronic musculoskeletal pain […]

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A Double-Blind, Randomized, Placebo-Controlled Study to Assess the Efficacy of a Nerve Support Formula on Neuropathic Pain in Individuals Suffering from Type II Diabetes Mellitus.

The primary objective of the present study was to evaluate the effects of a Nerve Support Formula NeuropAWAY on diabetic neuropathic pain.

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The benefits of making peace with pain: Chronic pain acceptance moderates the indirect effect of perceived burdensomeness between pain severity and suicidal cognitions.

The purpose of this study was 1) to examine the degree to which perceived burdensomeness mediates the relationship between pain severity and suicidal cognitions, and 2) to determine whether this […]

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Relationship, differences, and agreement between objective and subjective sleep measures in chronic spinal pain patients with comorbid insomnia: a cross-sectional study.

Sleep disturbances are one of the most frequent reported problems in people with nonspecific chronic spinal pain (nCSP) and presents an additional treatment challenge. Interventions targeting sleep problems are mainly […]

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A randomized controlled trial of hand/foot-cooling by hilotherapy to prevent oxaliplatin-related peripheral neuropathy in patients with malignancies of the digestive system.

Both acute and chronic symptoms of oxaliplatin-induced peripheral neuropathy (OIPN) affect patients’ treatment dose and duration as well as quality-of-life. Hand/foot-cooling has been shown to reduce taxane-induced peripheral neuropathy but […]

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