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Evaluation of white matter integrity by using diffusion tensor imaging in spontaneous intracranial hypotension.

The aim is to investigate whether there is a microstructural change in the white matter pathways in patients with spontaneous intracranial hypotension (SIH). Additionally, the relationship between conventional magnetic resonance […]

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The N-type calcium channel rises from the ashes.

Chronic pain is a debilitating condition that affects up to 1.5 billion people globally. Advancing pain management depends on a thorough understanding of the types of pain experienced by patients […]

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Reinvigorating drug development around NGF signaling for pain.

Nerve growth factor (NGF) signaling is a clinically validated target for the treatment of several prevalent types of chronic pain; however, addressing safety concerns remain a key challenge. In this […]

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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model.

Marfan Syndrome (MFS) is a connective tissue disorder due to mutations in fibrillin-1 (), where a missense mutation ( ) can result in systemic increases in the bioavailability and signaling […]

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Mercapto-NSAIDs generate a non-steroidal anti-inflammatory drug (NSAID) and hydrogen sulfide.

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the frontline treatments for inflammation and pain. Hydrogen sulfide (HS) and related persulfide (RS-SH) are important mediators of antioxidant response and protect cells from […]

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Individual Differences in Placebo Analgesia: Functional Connectivity and Neural Mechanisms [Letter].

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Comparison of Two Different Neuromodulation Treatments in Patients With Acute Zoster-Related Trigeminal Neuropathic Pain and Pain Catastrophizing.

This study aimed to compare the efficacy of two neuromodulation techniques, peripheral nerve stimulation (PNS) and pulsed radiofrequency (PRF), in patients with acute zoster-related trigeminal neuropathic pain with pain catastrophizing.

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EXPRESS: Upregulation of LRRC8A in the anterior cingulate cortex mediates chronic visceral pain in adult male mice with neonatal maternal deprivation.

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder primarily characterized by chronic visceral pain. Studies have reported that the anterior cingulate cortex (ACC) is involved in chronic visceral pain, […]

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Experimentally induced pain and paresthesia respond differently to parameter changes of cuff-based compression in pain-free young individuals.

Neuropathic pain is a significant therapeutic challenge due to the co-occurrence with other neurological symptoms such as paresthesia. Human-based models such as cuff algometry can enhance our understanding of pain-paresthesia […]

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Chronic musculoskeletal pain and its association with cognitive function and sarcopenia in older adults: characterization and change over three months.

Pain, cognitive impairment, and sarcopenia share common risk factors and neurophysiological processes, but studies investigating cognition and sarcopenia in older adults with pain are scarce. This study’s main aim was […]

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