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Pain-on-a-Chip: A microfluidic device for neuron differentiation and functional discrimination in animal models of chronic pain.

Chronic pain is a global health issue that is poorly understood and challenging to treat. Improving pain classification and treatment requires new strategies that objectively discriminate between pain conditions and […]

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The Therapeutic Potential of Cannabidiol in the Management of Temporomandibular Disorders and Orofacial Pain.

: Temporomandibular disorders (TMDs) are a group of conditions affecting the temporomandibular joint (TMJ) and associated muscles, leading to pain, restricted jaw movement, and impaired quality of life. Conventional treatments, […]

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The Relationship Between Metabolic Syndrome and Pain Catastrophizing in Psoriatic Arthritis.

Psoriatic arthritis (PsA) is a complex inflammatory disease often associated with metabolic syndrome (MetS). It has been demonstrated that pain catastrophizing (PC), characterized by an exaggerated negative cognitive and emotional […]

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Botulinum Toxin Therapy: A Comprehensive Review on Clinical and Pharmacological Insights.

Botulinum toxin (BoNT), produced by Clostridium botulinum, has transitioned from being a lethal neurotoxin to a versatile therapeutic agent. Its ability to inhibit neurotransmitter release by targeting Soluble N-ethylmaleimide-sensitive factor […]

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Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2-Mediated cAMP-PKA Signaling in the Spinal Cord Microenvironment.

Spinal cord injury (SCI) has a high mortality and disability rate and can result in severe neurological deficits and complications. The process of SCI is complex and has a long […]

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An Emerging Perspective on the Role of Fascia in Complex Regional Pain Syndrome: A Narrative Review.

Complex Regional Pain Syndrome (CRPS) is a debilitating pain disorder involving chronic inflammation, neural sensitization and autonomic dysfunction. Fascia, a highly innervated connective tissue, is increasingly recognized for its role […]

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Clinical and Molecular Barriers to Understanding the Pathogenesis, Diagnosis, and Treatment of Complex Regional Pain Syndrome (CRPS).

Complex regional pain syndrome (CRPS) is an idiopathic, highly debilitating chronic disorder with persistent regional pain accompanied by a combination of sensory, motor, and autonomic abnormalities. It is not only […]

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Efficacy of Sodium Channel-Selective Analgesics in Postoperative, Neuralgia, and Neuropathy-Related Pain Management: A Systematic Review and Literature Review.

Postoperative pain is a prevalent problem, often lasting from days to years. To minimize opioid use and associated risks of dependency, Enhanced Recovery After Surgery (ERAS) protocols increasingly incorporate multimodal […]

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The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications.

Endometriosis is a complex gynecological disorder characterized by endometrial-like tissue growing outside the uterus, leading to chronic pain, infertility, and reduced quality of life. Its pathophysiology involves genetic, epigenetic, immune, […]

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Uncharted Territory: Evaluating High Cervical Closed-Loop Spinal Cord Stimulation for Chronic Multisite, Non-contiguous Pain.

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