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Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping.

Osteoarthritis (OA) is a chronic condition in which pain significantly affects quality of life, often leading to reduced physical activity and disability. Globally, an estimated 595 million people are affected, […]

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The role of nerve transfers in chronic nerve compression syndromes.

Compression neuropathy is a common problem that results in impaired axonal conduction, and with time, numbness, tingling and weakness from muscle atrophy. Supercharge reverse end-to-side (SETS) nerve transfers have emerged […]

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P2Y12-mediated HIV gp120 and ddC-induced neuropathic pain improved by esculin.

We studied whether esculin (ES) has the effect of alleviating peripheral neuropathic pain (NP) in rat models of HIV glycoprotein 120 (gp120) together with zalcitabine (2′,3′-dideoxycytidine; ddC) treatment and explored […]

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Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.

Neuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated […]

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Bridging Gaps in Pain Management: The Effectiveness of Educational Intervention for Nurses in a Teaching Hospital of Low- and Middle-Income Countries.

Regular on-the-job training and educational courses may improve nurses’ knowledge and practice regarding pain assessment and initial treatment. To assess the impact of a newly developed educational course in terms […]

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Intradermally injected abobotulinumtoxinA administered preemptively before surgery alleviates post-surgical pain and normalizes behavior in a translational animal model.

Previously, abobotulinumtoxinA (aboBoNT-A) injected intraoperatively resulted in effective, but delayed post-surgical analgesia in pigs. Here, we explore the efficacy of preemptively administered aboBoNT-A in intact animals on pain and associated […]

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Activation of K channels in pain modulation: a systematic review of preclinical studies.

To systematically review the involvement of K channel activation in pain modulation in preclinical studies.

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Intra-somatosensory cortical circuits mediating pain-induced analgesia.

Pain in one part of the body profoundly diminishes the sensation of pain in other parts of the body in humans. Here, we found that pain-related behaviors in hindpaw are […]

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Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials.

Cannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy. This review aims to assess the current clinical trials […]

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Deficiency of intestinal alkaline phosphatase affects behavior and microglia activity in mice.

The gut microbiota plays crucial roles in the development and functions of the central nervous system (CNS) as well as in modulation of neurobehavior in heath and disease. The gut […]

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