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Advances in Formulations of Microneedle System for Rheumatoid Arthritis Treatment.

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation, eventually leading to severe disability and premature death. At present, the treatment of RA is mainly to […]

Identifying Patient Characteristics Associated With Opioid Use to Inform Surgical Pain Management.

Balancing surgical pain management and opioid stewardship is complex. Identifying patient-level variables associated with low or no use can inform tailored prescribing.

Latin America consensus statement inflammatory bowel disease: importance of timely access to diagnosis and treatment.

Inflammatory bowel diseases (IBDs) are chronic conditions that negatively interferes with the quality of life of the patients, on a physical, emotional, and social level. Its symptoms can vary including […]

A novel animal model of neuropathic corneal pain-the ciliary nerve constriction model.

Neuropathic pain arises as a result of peripheral nerve injury or altered pain processing within the central nervous system. When this phenomenon affects the cornea, it is referred to as […]

Advancements in Understanding and Classifying Chronic Orofacial Pain: Key Insights from Biopsychosocial Models and International Classifications (ICHD-3, ICD-11, ICOP).

In exploring chronic orofacial pain (COFP), this review highlights its global impact on life quality and critiques current diagnostic systems, including the ICD-11, ICOP, and ICHD-3, for their limitations in […]

The Effect of Mechanical Stress on Hyaluronan Fragments’ Inflammatory Cascade: Clinical Implications.

It is a common experience, reported by patients who have undergone manual therapy that uses deep friction, to perceive soreness in treatment areas; however, it is still not clear what […]

Aerobic Exercise and Neuropathic Pain: Insights from Animal Models and Implications for Human Therapy.

This narrative review explores the complex relationship between aerobic exercise (AE) and neuropathic pain (NP), particularly focusing on peripheral neuropathies of mechanical origin. Pain, a multifaceted phenomenon, significantly impacts functionality […]

Rewarding approach behaviour attenuates the return of pain-related avoidance after successful extinction with response prevention.

After successful exposure treatment for chronic pain, pain-related fear and avoidance may return, i.e., relapse may occur. This return of fear and avoidance may be modulated by various post-treatment factors. […]

Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and Opioid Consumption.

Children constitute a special group in pain therapy. Single nucleotide polymorphisms that are associated with differences in postoperative, inflammatory pain perception and opioid requirement are the A118G SNP in the […]

The Impact of UFP-512 in Mice with Osteoarthritis Pain: The Role of Hydrogen Sulfide.

The pain-relieving properties of opioids in inflammatory and neuropathic pain are heightened by hydrogen sulfide (HS). However, whether allodynia and functional and/or emotional impairments related to osteoarthritis (OA) could be […]

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