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Papers of the Week

Papers: 23 Dec 2023 - 29 Dec 2023


Front Neurosci



A novel animal model of neuropathic corneal pain-the ciliary nerve constriction model.


Seyed-Razavi Y, Kenyon BM, Qiu F, Harris DL, Hamrah P


Neuropathic pain arises as a result of peripheral nerve injury or altered pain processing within the central nervous system. When this phenomenon affects the cornea, it is referred to as neuropathic corneal pain (NCP), resulting in pain, hyperalgesia, burning, and photoallodynia, severely affecting patients’ quality of life. To date there is no suitable animal model for the study of NCP. Herein, we developed an NCP model by constriction of the long ciliary nerves innervating the eye.