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Reviving Intervertebral Discs: Treating Degeneration Using Advanced Delivery Systems.

Intervertebral disc degeneration (IVDD) is commonly associated with many spinal problems, such as low back pain, and significantly impacts a patient’s quality of life. However, current treatments for IVDD, which […]

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Curiosity: primate neural circuits for novelty and information seeking.

For many years, neuroscientists have investigated the behavioural, computational and neurobiological mechanisms that support value-based decisions, revealing how humans and animals make choices to obtain rewards. However, many decisions are […]

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Pain in the joints and beyond; the challenge of rheumatoid arthritis.

Pain is a common and often debilitating symptom for people living with rheumatoid arthritis. Although pain is a generic feature of inflammation and often improves with successful treatment that targets […]

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Pressure pain sensitivity and chronotype – a population-based study of middle-aged Finns.

Evening chronotype individuals experience pain more often than morning chronotypes, but relationships with pain sensitivity have rarely been studied. We examined whether chronotype is associated with pressure pain sensitivity, with […]

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Economic evaluation of videoconference group Acceptance and Commitment Therapy and Behavioral Activation Therapy for Depression versus usual care among adults with chronic low back pain plus comorbid depressive symptoms.

Chronic pain and depression are frequently comorbid conditions associated with significant healthcare and social costs. This study examined the cost-utility and cost-effectiveness of videoconference-based group forms of Acceptance and Commitment […]

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Chondroitin sulfate and caseinophosphopeptides doped polyurethane-based highly porous 3D scaffolds for tendon-to-bone regeneration.

Tendon disorders are common injuries, which can be greatly debilitating as they are often accompanied by great pain and inflammation. Moreover, several problems are also related to the laceration of […]

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Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy.

Post-traumatic trigeminal neuropathy (PTTN) is a type of chronic pain caused by damage to the trigeminal nerve. A previous study reported that pretreatment with anti-high mobility group box-1 (HMGB1) neutralizing […]

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Examining reactivity and recovery patterns of pain-evoked cortisol and alpha-amylase trajectories: Relations between psychological markers of risk and resilience.

Chronic low back pain (cLBP) is one of the leading causes of disability globally and represents an enormous burden to aging adults. While numerous factors contribute to cLBP, dysregulation in […]

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Mental health outcomes of endometriosis patients during the COVID-19 pandemic: Impact of pre-pandemic central nervous system sensitization.

To correlate pain-related phenotyping for central nervous system sensitization in endometriosis-associated pain with mental health outcomes during the COVID-19 pandemic, the prospective Endometriosis and Pelvic Pain Interdisciplinary Cohort (EPPIC, ClinicalTrials.gov […]

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The impact of patient race, patient socioeconomic status, and cognitive load of physician residents and fellows on chronic pain care decisions.

Social stereotypes are more likely to influence decision-making under conditions of high cognitive load (i.e., mental workload), such as in medical settings. We examined how patient race, patient socioeconomic status […]

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