Accepted

Neuronal electrochemical signals involve the flux of sodium ions through voltage-gated sodium channels (Na) located in the neurolemma. Of the nine sodium channel subtypes, Na-1.7, 1.8, and 1.9 are predominantly […]

Current definitions of migraine that are based mainly on clinical characteristics do not account for other patient’s features such as those related to an impaired quality of life, due to […]

Most chemotherapeutic drugs are potent and have a very narrow range of dose safety and efficacy, most of which can cause many side effects. Chemotherapy-induced peripheral neuropathy (CIPN) is the […]

Trigeminal neuralgia (TN) is the most severe type of neuropathic pain. The trigeminal ganglion (TG) is a crucial target for the pathogenesis and treatment of TN. The colony-stimulating factor 1 […]

Neuropathic pain, a prevalent chronic condition in clinical settings, has attracted widespread societal attention. This condition is characterized by a persistent pain state accompanied by affective and cognitive disruptions, significantly […]

Previous studies have established a core outcome set for paediatric chronic pain clinical trials. The aim of this research was to establish which outcomes young people and parents considered important […]

Innate defensive behavior is important for animal survival. The Vglut neurons in the ventral tegmental area (VTA) have been demonstrated to play important roles in innate defensive behaviors, but the […]

Laquinimod modulates CNS inflammatory pathways thought to be involved in the pathology of Huntington’s disease. Studies with laquinimod in transgenic rodent models of Huntington’s disease suggested improvements in motor function, […]

Endometriosis is a chronic gynecological syndrome characterized by endometrial cell invasion of the extra-uterine milieu, pelvic pain and infertility. Treatment relies on either symptomatic drugs or hormonal therapies, even though […]

Elucidating the mechanism of neuropathic pain (NeP) is crucial as it can result in motor dysfunction and negatively impact quality of life in patients with spinal cord injury (SCI). Although […]