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Unpacking the Itch Score: A Critical Examination of Routine Itch Measurement in Dermatology Practice.

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Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies.

There is significant interest in the potential of glucagon-like peptide 1 receptor agonists (GLP-1A) to improve outcomes in osteoarthritis. We systematically reviewed the evidence from pre-clinical and human studies for […]

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Development and pharmacological characterization of novel multi- calcitonin gene-related peptide and pituitary adenylate cyclase-activating peptide receptor antagonists.

This study aimed to provide proof-of-concept that multi-receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene-related peptide (CGRP) or pituitary adenylate cyclase-activating peptide […]

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Peripherally acting anti-CGRP monoclonal antibodies attenuate cortical resting-state connectivity in migraine patients.

In about half of migraine patients, anti-calcitonin gene-related peptide monoclonal antibodies reduce monthly migraine days by >50%. In these patients, this class of drugs may change cortical functions by decreasing […]

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Spinal KCC2 Mediates the Modulation Effect of HDAC2 on Bone Cancer Pain in Rats.

Bone cancer pain is a global medical concern with limited treatment options that significantly reduce the quality of life for cancer patients. Therefore, identifying a promising therapeutic target for bone […]

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Illness perceptions among individuals with endometriosis and their longitudinal associations with psychological distress and pain.

This study examined the illness perceptions held by individuals living with endometriosis, and their associations with psychological distress and chronic pain, over time. At baseline, 408 participants provided demographic and […]

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Hyaluronic acid: Function and location in the urothelial barrier for bladder pain syndrome/interstitial cystitis, an in vitro study.

Disruption of the glycosaminoglycan (GAG)-layer and urothelial barrier is an important aspect of the pathophysiology of bladder pain syndrome/ interstitial cystitis. Intravesical hyaluronic acid (HA) is often used in treatments […]

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Gene Expression Changes Precede Elevated Mechanical Sensitivity in the Mouse Intervertebral Disc Injury Model.

Back pain after intervertebral disc (IVD) injury is a common clinical problem. Previous work examining early molecular changes post injury mainly used a candidate marker approach.

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fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura.

Migraine with aura (MwA) is a common and severely disabling neurological disorder, characterised by transient yet recurrent visual disturbances, including scintillating scotomas, flickering photopsias, and complex geometric patterns. These episodic […]

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Do antithrombotic drugs have a role in migraine prevention? A systematic review.

To explore the available evidence on the role of antithrombotics as migraine preventive medication.

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