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Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study.

Itch sensitization has been reported in patients with chronic allergic skin diseases and observed in a mouse model of allergic contact dermatitis (ACD). There is evidence suggesting that neuroimmune interactions […]

Early maladaptive schemas in female patients with migraine and tension-type headache.

Chronic headache is a serious clinical problem in women which psychological factors play major role and requires an approach with bio-psycho-social integrity. Psychiatric comorbidities such as anxiety disorder and major […]

A cross-sectional and longitudinal integrated study on brain functional changes in a neuropathic pain rat model.

Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions and even causes mental dysfunctions such as depression and anxiety […]

A comprehensive patient-specific prediction model for temporomandibular joint osteoarthritis progression.

Temporomandibular joint osteoarthritis (TMJ OA) is a prevalent degenerative disease characterized by chronic pain and impaired jaw function. The complexity of TMJ OA has hindered the development of prognostic tools, […]

Virtual Reality Therapy for the Management of Chronic Spinal Pain: Systematic Review and Meta-Analysis.

The effectiveness of virtual reality (VR) therapy in adults with chronic spinal pain (CSP) is unclear.

Applications of Artificial Intelligence in Pain Medicine.

This review explores the current applications of artificial intelligence (AI) in the field of pain medicine with a focus on machine learning.

The Gut Microbiota and Chronic Pain.

To examine the effects and interactions between gut microbia and chronic pain.

Histamine- and Pruritogen-induced Itch is Inhibited by a TRPM8 Agonist in Humans: A Randomized, Vehicle-controlled Trial.

Allergies often present challenges in managing itch and the effects of histamine. Cooling agents that act via TRPM8 agonism have shown potential in itch management. However, animal studies on itch […]

Erector spinae plane block for postoperative pain.

Acute and chronic postoperative pain are important healthcare problems, which can be treated with a combination of opioids and regional anaesthesia. The erector spinae plane block (ESPB) is a new […]

Musculoskeletal pain in 13-year-old children: the generation R study.

Musculoskeletal (MSK) pain is a common reason for consultation in general practice and frequently reported in children and adolescents. This study examined the prevalence of MSK pain in 13-year-old children […]

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