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Papers of the Week
Histamine- and Pruritogen-induced Itch is Inhibited by a TRPM8 Agonist in Humans: A Randomized, Vehicle-controlled Trial.
Authors
Lee S, Wei ET, Selescu T, Babes A, Park J, Kim J, Chung B, Park C, Kim HAbstract
Allergies often present challenges in managing itch and the effects of histamine. Cooling agents that act via TRPM8 agonism have shown potential in itch management. However, animal studies on itch have limitations, as non-humans cannot communicate subjective events, and their fur-coated skin differs from human skin. Human studies offer more direct and reliable information.