I am a
Home I AM A Search Login

Papers of the Week

Papers: 10 Feb 2024 - 16 Feb 2024

2024 Feb 12

Br J Dermatol


Histamine- and Pruritogen-induced Itch is Inhibited by a TRPM8 Agonist in Humans: A Randomized, Vehicle-controlled Trial.


Lee S, Wei ET, Selescu T, Babes A, Park J, Kim J, Chung B, Park C, Kim H


Allergies often present challenges in managing itch and the effects of histamine. Cooling agents that act via TRPM8 agonism have shown potential in itch management. However, animal studies on itch have limitations, as non-humans cannot communicate subjective events, and their fur-coated skin differs from human skin. Human studies offer more direct and reliable information.