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Unveiling the Mechanisms of Pain in Endometriosis: Comprehensive Analysis of Inflammatory Sensitization and Therapeutic Potential.

Endometriosis is a complicated, estrogen-dependent gynecological condition with a high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women’s physical and mental health and exacerbates […]

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Association of Chronic Pain with Motor Symptom Severity in Parkinson’s Disease: An Exploratory Cross-Sectional Analysis.

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms like bradykinesia, tremor, rigidity, and postural instability. Additionally, PD severely impacts physical abilities and independence. Chronic pain, affecting 67.6% […]

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Mental and Physical Well-Being of Partners of People Living with Chronic Pain: A Narrative Review.

This narrative review aims to explore the mental and physical well-being of partners of individuals living with chronic pain. Chronic pain not only affects those who suffer from it, but […]

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A Narrative Review on Manufacturing Methods Employed in the Production of Mesenchymal Stromal Cells for Knee Osteoarthritis Therapy.

Knee osteoarthritis (OA) is a chronic, progressive, inflammatory, and degenerative whole-joint disease. Early-stage OA treatments typically include physiotherapy, weight-loss, pain relief medications, and intra-articular knee injections, such as corticosteroids, hyaluronic […]

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Chronic pain classification using PPG and ECG parameters selected via hybrid feature selection.

Current chronic pain intensity assessment methods are large based on self-description, which is the gold-standard in clinical practice. However, for patients who lack communication ability or consciousness, this challenging task […]

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Chronic Stress and Headaches: The Role of the HPA Axis and Autonomic Nervous System.

Chronic stress significantly influences the pathogenesis of headache disorders, affecting millions worldwide. This review explores the intricate relationship between stress and headaches, focusing on the dysregulation of the hypothalamic-pituitary-adrenal (HPA) […]

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Critical Role of p38α MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision.

Deeper understanding of the mechanisms of postoperative pain is critical for developing more effective pain management strategies. The present animal study explored the function of four p38 mitogen-activated protein kinase […]

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Electroacupuncture Modulates Programmed Cell Death 1 Ligand 1 on Peripheral and Central Nervous Systems in a Mouse Fibromyalgia Pain Model.

Fibromyalgia, a chronic condition that causes long-lasting pain over several months, is a global medical issue with both personal and societal implications. It is one of the hardest types of […]

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Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis.

The nervous system has a complex interplay with the immune system, especially at barrier sites such as the skin. This allows it to play a role in a variety of […]

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Neuroinflammatory and Immunological Aspects of Fibromyalgia.

Fibromyalgia is a common, high-impact condition of chronic widespread pain and sensory dysfunction associated with altered central and peripheral sensory processing. A growing body of evidence supports the role of […]

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