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Schober test is not a valid assessment tool for lumbar mobility.

The Schober test is considered reliable in evaluating lumbar mobility and its impairment. Especially in patients with chronic low back pain (cLBP) identification of functional restriction is important. We aimed […]

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Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain.

Pain is a major symptom in cancer patients, and cancer-induced bone pain (CIBP) is the most common type of moderate and severe cancer-related pain. The current available analgesic treatments for […]

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Spinal Nmur2-positive neurons play a crucial role in mechanical itch.

The dorsal spinal cord is crucial for the transmission and modulation of multiple somatosensory modalities, such as itch, pain, and touch. Despite being essential for the well-being and survival of […]

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Meeting Report: Highlights of 12th World Congress of Itch.

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Reciprocal association between chronic pain and health insurance type in a population-based longitudinal cohort study.

Chronic pain is a widespread condition limiting adults’ daily activities and labor force participation. In the US, withdrawal from the workforce could be associated with loss of health insurance coverage, […]

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The complement system: a potential target for the comorbidity of chronic pain and depression.

The mechanisms of the chronic pain and depression comorbidity have gained significant attention in recent years. The complement system, widely involved in central nervous system diseases and mediating non-specific immune […]

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Our understanding of microglia involvement in neuropathic pain has expanded.

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Comparison of migraine with left- versus right-sided headache: A cross-sectional study.

The goal of this study was to clarify whether clinical differences exist between patients with migraine who experience headache that is typically left-sided (“left-migraine”) versus right-sided (“right-migraine”) during attacks.

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The purinergic receptor P2X3 promotes facial pain by activating neurons and cytokines in the trigeminal ganglion.

The mechanism underlying allodynia/hyperalgesia caused by dental pulpitis has remained enigmatic. This investigation endeavored to characterize the influence of the purinergic receptor P2X3 on pain caused by experimental pulpitis and […]

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The impact of primary headaches on disability outcomes: a literature review and meta-analysis to inform future iterations of the Global Burden of Disease study.

The burden and disability associated with headaches are conceptualized and measured differently at patients’ and populations’ levels. At the patients’ level, through patient-reported outcome measures (PROMs); at population level, through […]

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