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To examine the immediate effects of a comprehensive pain course on medical students’ pre-existing perceptions and attitudes toward pain patients and opioid management.
Learn More >The ability to perceive temperature is crucial for most animals. It enables them to maintain their body temperature and swiftly react to noxiously cold or hot objects. Caenorhabditis elegans is […]
Learn More >Nav1.7 Modulator Bearing a 3-Hydroxyindole Backbone Holds the Potential to Reverse Neuropathic Pain.
Chronic pain is a growing global health problem affecting at least 10% of the world’s population. However, current chronic pain treatments are inadequate. Voltage-gated sodium channels (Navs) play a pivotal […]
Learn More >Secreted microRNAs (miRNAs) have been detected in various body fluids including the cerebrospinal fluid, yet their direct role in regulating synaptic transmission remains uncertain. We found that intrathecal injection of […]
Learn More >Pain science education (PSE) provides people with an understanding of “how pain works” grounded in the biopsychosocial model of pain; it has been demonstrated to improve outcomes in musculoskeletal pain […]
Learn More >Botulinum toxin (BoNT), a presynaptic inhibitor of acetylcholine (Ach) release at the neuromuscular junction (NMJ), is a successful and safe drug for the treatment of several neurological disorders. However, a […]
Learn More >The pressing need for safer, more efficacious analgesics is felt worldwide. Preclinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before […]
Learn More >Opioids are commonly prescribed to patients with chronic pain. Chronic opioid usage comes with a slew of serious side effects, including opioid-induced hyperalgesia (OIH). The patients with long-term opioid treatment […]
Learn More >Generative artificial intelligence (AI) models offer potential assistance in pain research data acquisition, yet concerns persist regarding data accuracy and reliability. In a comparative study, we evaluated open generative AI […]
Learn More >Management of patients with chronic musculoskeletal pain (CMP) remains a challenge in general practice. The general practitioner (GP) often experiences diagnostic uncertainty despite frequently referring patients with CMP to specialized […]
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