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Sex moderates the association between quantitative sensory testing and acute and chronic pain after total knee/hip arthroplasty.

Acute postsurgical pain (APSP) may persist over time and become chronic. Research on predictors for APSP and chronic postsurgical pain (CPSP) has produced inconsistent results. This observational study aimed to […]

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Current and emerging drugs for the treatment of pruritus: an update of the literature.

Pruritus, particularly in its chronic form, often imposes significant suffering and reductions in patients’ quality of life. The pathophysiology of itch is varied depending on disease context, creating opportunities for […]

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Changes in SLITRK1 Level in the Amygdala Mediate Chronic Neuropathic Pain-Induced Anxio-Depressive Behaviors in Mice.

Comorbid chronic neuropathic pain (NPP) and anxio-depressive disorders (ADD) have become a serious global public-health problem. The SLIT and NTRK-like 1 (SLITRK1) protein is important for synaptic remodeling and is […]

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Cannabis oil extracts for chronic pain: what else can be learned from another structured prospective cohort?

The use of medicinal cannabis for managing pain expands, although its efficacy and safety have not been fully established through randomized controlled trials.

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Methyl jasmonate ameliorates pain-induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation.

Orofacial pain with high prevalence is one of the substantial human health issues. The importance of this matter became more apparent when it was revealed that orofacial pain, directly and […]

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Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis.

To assess whether systemic lupus erythematosus (SLE) may be genetically causally associated with migraine, including the two primary subtypes: migraine with aura (MWA) and migraine without aura (MWoA).

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Manual acupuncture ameliorates inflammatory pain by upregulating adenosine A receptor in complete Freund’s adjuvant-induced arthritis rats.

Adenosine A receptor (AR) exerts analgesic, anti-inflammatory, and anti-nociceptive effects. In this study, we determined the analgesic mechanism of manual acupuncture (MA) in rats with complete Freund’s adjuvant (CFA)-induced arthritis […]

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The Neurophysiology of Interoceptive Disruptions in Trauma-Exposed Populations.

In the aftermath of psychological trauma, many individuals experience perturbations in interoception, a term that broadly references the ability to accurately detect body signals and integrate these signals with emotional […]

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Does pain intensity after total knee arthroplasty depend on somatosensory functioning in knee osteoarthritis patients? A prospective cohort study.

The objective of this study is to determine whether the change in pain intensity over time differs between somatosensory functioning evolution profiles in knee osteoarthritis (KOA) patients undergoing total knee […]

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Actions of remimazolam on inhibitory transmission of rat spinal dorsal horn neurons.

Remimazolam is an ultra-short benzodiazepine that acts on the benzodiazepine site of γ-aminobutyric acid (GABA) receptors in the brain and induces sedation. Although GABA receptors are found localized in the […]

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