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Gender Bias in Pain Management: The Case for Updating Analgesia Guidelines for Intrauterine Device Insertion Procedures.

Gender bias in pain management represents a significant challenge in healthcare resulting in the underestimation of women’s pain during procedures including intrauterine device insertions. In this setting, the gender pain […]

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Editorial: Pharmacological advances to treat pathological pain.

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Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis.

Neuronal signals have emerged as critical factors that regulate group 3 innate lymphoid cell (ILC3) response and tissue homeostasis, but the molecular mechanisms underlying this regulation remain largely elusive. Here, […]

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Viscoelastic Hydrogel Promotes Disc Mechanical Homeostasis Repair and Delays Intervertebral Disc Degeneration via the Yes-Associated Protein Pathway.

Intervertebral disc degeneration (IDD) process is accompanied by overactive inflammation and mechanical instability of the nucleus pulposus (NP). Current treatments do not fully restore the biomechanical environment of discs, limiting […]

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Bidirectional Mendelian randomization study reveals interplay between multisite chronic pain and Post-traumatic stress disorder.

To determine the causal relationship between multisite chronic pain (MCP) and post-traumatic stress disorder (PTSD) using Mendelian Randomization (MR) analysis. Genome-wide summary statistics for MCP and PTSD were obtained. Linkage […]

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Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations.

Chronic pain is associated with persistent alterations in brain structure and function. However, existing research has not fully explored the relationship between brain network topological properties and clinical symptoms in […]

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Brain Mechanisms of Fear Reduction Underlying Habituation to Pain in Humans.

Habituation to painful stimuli reflects an endogenous pain alleviation mechanism, and reduced pain habituation has been demonstrated in many chronic pain conditions. In ethology, animals exhibit reduced fear responses while […]

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Effects of Deinorgestrel Treatment of Endometriosis on Ovarian Function, Inflammatory Factors, and Pregnancy Rate in Patients.

To compare the effects of deinorgestrel and Guizhi Fuling Capsules on ovarian function, inflammatory variables, and the rate of conception in clients receiving endometriosis treatment.

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Widespread and Prolonged Pain May Reduce Brain Clearance Capacity Only via Sleep Impairment: Evidence from Participants with Knee Pain.

The brain is key in the pain-sleep relationship, and sleep is needed for glymphatic clearance. However, no studies have examined how pain relates to the glymphatic system (GS). Characterizing the […]

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Modified Feature Selection for Improved Classification of Resting-State Raw EEG Signals in Chronic Knee Pain.

Diagnosing pain in research and clinical practices still relies on self-report. This study aims to develop an automatic approach that works on resting-state raw EEG data for chronic knee pain […]

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